Correlation of performance of students in comprehensive examinations, general weighted average grade to the physician licensure examinations in a medical school with an organ system integrated curriculum

OBJECTIVES:  1. To describe the performance of medical students in comprehensive examinations given after each learning unit or year level.  2. To correlate the scores of the students in the comprehensive examinations to the general weighted average grade (GWAG) for the same learning unit. 3. To correlate the scores in the subject-based part of the comprehensive examinations to the scores in the Physicians Licensure Examination (PLE)   METHODS: The scores of graduates of the University of the Philippines Manila College of Medicine (UPCM) for the years 2009-2011 in the comprehensive examinations, their general weighted average grade per learning unit, and scores in the PLE were retrieved and analyzed. Correlation coefficients of comprehensive examination score and GWAG, and comprehensive examination score and PLE score were computed. RESULTS: A total of 434 out of 463 graduates from UPCM were included in this study. There was no trend observed in the performance of students in the comprehensive examinations as they progressed from one learning unit to the next. Performance in both portions of the comprehensive examinations was observed to have significant correlation to students' LU GWAG for most of the learning units, with the exception of LU 6 and LU 7 for Class B. Performance in the subject-based portion of the comprehensive examinations was observed to have significant correlation to students' PLE scores. CONCLUSIONS: The students' scores in the comprehensive examinations had moderate to strong correlation with the GWAG for the corresponding learning unit. Similarly, scores in the subject-based portion of the comprehensive examination had moderate to strong correlation with PLE scores.

Comparison of performance of graduates in traditional curriculum and graduates in an organ system integrated curriculum from the same medical school on the physician licensure examinations

Objective. To compare the performance of graduates in a traditional curriculum and graduates in an organ system integrated curriculum from the same school on the national medical licensure examination. Methods. The scores of graduates of the University of the Philippines Manila College of Medicine in 2008, taught in the traditional medical curriculum were compared with those of the scores of graduates in 2009, taught under the organ system integrated curriculum, on the Physicians Licensure Examination (PLE) conducted by the Professional Regulation Commission (PRC). Average scores, and scores per subject were compared using t-test. Results. The graduates of the organ system integrated curriculum (2009) had higher average scores than the graduates of the traditional curriculum (2008). The former also had higher scores in Physiology, Legal Medicine, Pathology, Surgery, Obstetrics and Gynecology, and Pediatrics. The scores of the 2 groups were not significantly different in Biochemistry, Anatomy, Pharmacology and Medicine. The graduates of the traditional curriculum had higher scores in Microbiology and Preventive Medicine. Conclusion. The graduates of the organ system integrated curriculum (2009) had better over all performance in the physician licensure examinations than the graduates of the traditional curriculum (2008).

Correlation of National Medical Admission Test scores, general weighted average grade in pre-medicine courses, general weighted average grade in medicine and the Physician Licensure Examination scores among medical graduates of the University of the Philippines Manila-College of Medicine

OBJECTIVES: This study was conducted to examine the validity of the National Medical Admissions Test (NMAT) score, Pre-Medicine general weighted average grade (Pre-Med GWAG) in predicting the academic performance in medical school, as measured by the medical school general weighted average grade (Med GWAG) and Physician Licensure Examination (PLE). It also aimed to study which among the NMAT, pre-medicine GWAG and MedGWAG best correlates with PLE. METHODS: Records of graduates of th UPCM from 2004 to 2009 were retrieved and data regardin the following entry characteristics were collected: National Medical Admissions Test (NMAT) scores, pre-Medicine general weighted average grade (MedGWAG). Average and individual subject scores in the PLE were retrieved for this study. Statistical analysis using the Pearson correlation analysis was performed using STATA. RESULTS: The NMAT, MedGWAG and PLE scores of the direct and lateral entrants were not significantly different from each other. There was weak correlation between NMAT and Pre-Med GWAG and weak to moderate correlation between NMAT and Med GWAG. Except for the 2009 graduates where no correlation between NMAT and PLE scores was noted for 2004-2008 graduates. There was moderate to strong correlation between Pre-Med GWAG and Med GWAG and weak correlation between Pre-Med GWAG and PLE scores. There was strong correlation between Med GWAG and PLE scores. CONCLUSIONS: Pre-Med GWAG had higher correlations to Med GWAG than NMAT scores. In Terms of PLE scores, the Medicine GWAG showed the highest correlation followed by Pre-Med GWAG, then NMAT scores.

Intravenous methylprednisolone versus oral prednisone for initial attacks of optic neuritis: A review of evidence

Objective: To review current available evidence that addresses the question regarding the efficacy of intravenous methylprednisolone and oral-prednisone treatment regimens in improving vision among optic-neuritis patients. Methods: A literature search for randomized controlled trials on the treatment of optic neuritis in adults using steroids was conducted. A total of 23 studies were identified in the search. Of these, the Optic Neuritis Treatment Trial (ONTT) was identified as the largest multicenter, randomized controlled trial that evaluated the effect of steroids in the treatment of optic neuritis in adults. The initial article regarding the results of this landmark study published in 1992 and follow-up reports focusing on the five-year and ten-year visual outcomes published in 1997 and 2004 were appraised for this review. Results: Treatment with high dose intravenous methylprednisolone followed by oral prednisone produced short-term accelerated visual recovery but provided no long-term benefit to vision. Most patients retained good to excellent vision following an attack of optic neuritis regardless of treatment received. A significantly increased risk of recurrence of optic neuritis in either eye (19 percent) was noted in the oral-prednisone treatment group. There were no significant differences among the treatment groups in the risk of development of clinically definite multiple sclerosis. Conclusion: Intravenous methylprednisolone followed by oral prednisone may be considered as treatment for patients with acute optic neuritis in whom there is a need to speed up recovery of vision. Considering that the use of oral prednisone alone was associated with an increased risk of recurrence of optic neuritis in either eye, no treatment is an option.

Leptina y sistema reproductivo / Leptin and the reproductive system

La leptina es una hormona proteica recientemente descubierta, la cual es producida por los adipocitos. Esta actúa regulando el apetito, el peso corporal y la termogénesis. Su posible rol como modulador en el eje reproductivo se ha inferido de una cepa de ratas carentes de leptina, que se caracterizan por ser obesas, diabéticas e infértiles y en las que el administrar esta hormona se producen cambios como disminución del apetito, aumento del gasto energético y recuperación de la fertilidad. Estos fenómenos han motivado una gran cantidad de estudios para establecer el rol la leptina en el sistema reproductivo. Se revisa la literatura existente sobre leptina y su acción sobre los cambios de peso corporal, pubertad, sistema nervioso central y periférico, ovarios y embarazo

Hematina en el tratamiento de la crisis aguda de la intoxicación plúmbica / Hematin in the treatment acute crisis the lead intoxication

Se trató exitosamente con hematina la crisis aguda en un paciente en estado de impregnación crónica por plomo. El paciente no había respondido previamente al tratamiento convencional de analgésicos y B-bloqueadores. Ocho horas después de la infusión intravenosa de 300 mg de hematina desaparecieron totalmente los síntomas abdominales y musculares. Este novedoso tratamiento de las crisis agudas de las intoxicaciones plúmbicas, está basado en el concepto de que la alteración de la biosíntesis del hemo es la más importante alteración metabólica en la intoxicación por plomo, y que, al igual que en las crisis agudas porfíricas, existiría una severa depleción del hemo, afectando la actividad de numerosas hemoproteínas, que podría explicar la sintomatología de esta intoxicación. Paralelamente a la mejoría clínica y dentro de las 30h posteriores a la infusión de hematina, se observó una importante normalización de la excreación de porfirinas y precursores. Sin embargo, la excreación urinaria de ácido 8 aminolevulínico y de porfobilinógeno volvió a elevarse a los niveles similares a los del comienzo de la crisis, pero sin observar manifestaciones clínicas.